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Makoto Sasaki Selected Research

neopeltolide

11/2014Programmed cell death induced by (-)-8,9-dehydroneopeltolide in human promyelocytic leukemia HL-60 cells under energy stress conditions.
6/2013Concise synthesis and biological assessment of (+)-neopeltolide and a 16-member stereoisomer library of 8,9-dehydroneopeltolide: identification of pharmacophoric elements.
11/2009Total synthesis and biological evaluation of (+)-neopeltolide and its analogues.

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Makoto Sasaki Research Topics

Disease

33Neoplasms (Cancer)
01/2022 - 10/2003
17Hemorrhage
05/2022 - 12/2009
15Stroke (Strokes)
03/2022 - 10/2007
15Inflammatory Bowel Diseases (Inflammatory Bowel Disease)
01/2022 - 04/2002
13Inflammation (Inflammations)
05/2022 - 02/2003
13Stomach Neoplasms (Stomach Cancer)
01/2016 - 08/2004
11Prostatic Neoplasms (Prostate Cancer)
04/2022 - 10/2014
10Atherosclerosis
05/2022 - 01/2011
9Multiple Myeloma
01/2022 - 05/2006
8Ciguatera Poisoning (Ciguatera)
02/2022 - 05/2002
8Ischemic Stroke
01/2022 - 06/2005
7Infections
01/2021 - 09/2005
7Carotid Stenosis (Carotid Artery Stenosis)
01/2020 - 11/2008
7Colitis
01/2017 - 02/2003
6Hypersensitivity (Allergy)
01/2022 - 05/2011
6Ulcerative Colitis
01/2022 - 12/2009
6Hepatocellular Carcinoma (Hepatoma)
01/2021 - 10/2003
6Ulcer
05/2018 - 10/2007
6Parkinson Disease (Parkinson's Disease)
07/2014 - 11/2002
5Necrosis
05/2022 - 07/2002
5Diarrhea
01/2022 - 07/2008
5Cardiovascular Diseases (Cardiovascular Disease)
01/2021 - 09/2019
5Pancreatic Neoplasms (Pancreatic Cancer)
09/2020 - 01/2008
5Lymphoma (Lymphomas)
11/2019 - 07/2005
5Glioblastoma (Glioblastoma Multiforme)
03/2019 - 06/2005
5Pathologic Constriction (Stenosis)
01/2019 - 05/2009
5Non-Erosive Reflux Disease
01/2019 - 11/2012
5Poisoning
12/2017 - 09/2006
5Carcinoma (Carcinomatosis)
03/2012 - 04/2002
5Neoplasm Metastasis (Metastasis)
06/2011 - 01/2008
4Coronary Artery Disease (Coronary Atherosclerosis)
08/2022 - 10/2015
4Aneurysm (Aneurysms)
07/2021 - 01/2011
4Infarction (Infarctions)
01/2020 - 01/2011
4Heartburn (Pyrosis)
01/2020 - 07/2015
4Gastroesophageal Reflux (GERD)
01/2016 - 01/2014
4Demyelinating Diseases (Demyelinating Disease)
08/2012 - 09/2009
3Cerebral Small Vessel Diseases
01/2022 - 12/2019
3Brain Ischemia (Cerebral Ischemia)
12/2021 - 05/2014
3Intracranial Hemorrhages (Intracranial Hemorrhage)
01/2021 - 03/2010
3Atrial Fibrillation
12/2020 - 10/2019
3Eosinophilia
03/2020 - 05/2008
3Disease Progression
01/2020 - 04/2018
3Alzheimer Disease (Alzheimer's Disease)
01/2019 - 05/2012
3Ischemia
08/2018 - 01/2014
3Colorectal Neoplasms (Colorectal Cancer)
04/2018 - 03/2015
3Embolism (Embolus)
01/2018 - 10/2007
3Type 2 Diabetes Mellitus (MODY)
10/2017 - 05/2013
3Schizophrenia (Dementia Praecox)
03/2016 - 09/2008
3Heart Failure
01/2016 - 04/2011
3Body Weight (Weight, Body)
12/2014 - 02/2010
3Adenocarcinoma of Lung
06/2014 - 02/2011
3Peptic Ulcer (Peptic Ulcers)
03/2014 - 08/2013

Drug/Important Bio-Agent (IBA)

13Proton Pump InhibitorsIBA
01/2020 - 01/2011
12Proteins (Proteins, Gene)FDA Link
01/2022 - 09/2005
12Protons (Proton)IBA
10/2020 - 11/2002
11Tissue Plasminogen Activator (Alteplase)FDA Link
03/2022 - 03/2010
9Biological ProductsIBA
02/2022 - 02/2003
7CiguatoxinsIBA
02/2022 - 05/2002
7Pharmaceutical PreparationsIBA
01/2020 - 01/2005
7LipidsIBA
01/2018 - 09/2012
7neuromelaninIBA
03/2016 - 07/2006
6oxidized low density lipoproteinIBA
05/2022 - 06/2013
6EnzymesIBA
01/2021 - 01/2009
6gambierolIBA
01/2017 - 12/2003
6CytokinesIBA
12/2013 - 02/2003
6Cell Adhesion Molecule-1IBA
03/2011 - 04/2002
4Biomarkers (Surrogate Marker)IBA
05/2022 - 01/2017
4DNA (Deoxyribonucleic Acid)IBA
02/2021 - 11/2005
4Immunoglobulin E (IgE)IBA
03/2020 - 04/2002
4Volatile Fatty AcidsIBA
01/2020 - 12/2013
4LigandsIBA
01/2020 - 02/2003
4Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
01/2019 - 02/2003
4Amyloid (Amyloid Fibrils)IBA
01/2019 - 01/2013
4MacrolidesIBA
12/2017 - 11/2009
4AcidsIBA
12/2017 - 04/2015
4Dextran SulfateIBA
12/2013 - 04/2003
3Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA
05/2022 - 04/2003
3AnticoagulantsIBA
02/2022 - 11/2013
3SteroidsIBA
01/2021 - 09/2014
3Anti-Bacterial Agents (Antibiotics)IBA
12/2019 - 07/2008
3Bevacizumab (Avastin)FDA Link
03/2019 - 06/2011
3Indicators and Reagents (Reagents)IBA
10/2018 - 08/2012
3Capsules (Microcapsules)IBA
05/2018 - 01/2008
3CholesterolIBA
01/2018 - 04/2003
3Oxygen (Dioxygen)IBA
01/2017 - 01/2011
3Bortezomib (Velcade)FDA Link
01/2016 - 05/2006
3Carbon MonoxideIBA
12/2015 - 08/2010
3neopeltolideIBA
11/2014 - 11/2009
3Myelin Basic ProteinIBA
08/2012 - 08/2010

Therapy/Procedure

30Therapeutics
01/2022 - 01/2005
16Drug Therapy (Chemotherapy)
01/2021 - 01/2008
13Proton Therapy
04/2022 - 08/2013
8Radiotherapy
04/2022 - 08/2013
7Carotid Endarterectomy
01/2020 - 06/2008
6Stents
02/2022 - 05/2009
3Renal Dialysis (Hemodialysis)
01/2022 - 10/2007
3Intensity-Modulated Radiotherapy (Radiotherapy, Intensity Modulated)
09/2020 - 10/2019
3Endarterectomy (Thromboendarterectomy)
01/2019 - 08/2011
3Traction
01/2016 - 04/2010
3Aftercare (After-Treatment)
03/2012 - 03/2010